Reversal of multidrug resistance by non-antitumor anthracycline analogs
Inaba, M.; Nagashima, K.; Sakurai, Y.; Fukui, M.; Yanagi, Y.
Gan 75(12): 1049-1052
1984
ISSN/ISBN: 0016-450X PMID: 6597118 Document Number: 232967
It was found that three synthetic anthracycline analogs lacking not only antitumor activity but also calcium-antagonizing action possessed an activity to potentiate vincristine cytotoxicity against vincristine-resistant P388 leukemia. ID-8279, one of these analogs, significantly reversed resistance to vincristine and daunorubicin by increasing their intracellular accumulation.
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