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Multidrug resistance reversal by 3-formylchromones in human colon cancer and human mdr1 gene-transfected mouse lymphoma cells

Baráth, Zán.; Radics, R.; Spengler, G.; Ocsovszki, I.; Kawase, M.; Motohashi, N.; Shirataki, Y.; Shah, A.; Molnár, József.

In Vivo 20(5): 645-649

2006

ISSN/ISBN: 0258-851X
PMID: 17091772
Document Number: 600689
Several new 3-formylchromone derivatives proved to be modifiers of multidrug resistance in mouse lymphoma cells and in human Colo320 colon cancer cells. There is apparently a structure-activity relationship between the antiproliferative multidrug resistance-reversing effect and the chemical structure of the 3-formylchromones. The total polar surface areas and the ground state dipole moments of the molecules are presumed to play a key role in the multidrug resistance-reversing effect. The log P values can provide an adequate explanation for the selective cytotoxicity against cancer cells.

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Ferreira, M-José.U.; Duarte, Nélia.; Gyémánt, N.; Radics, R.; Cherepnev, G.; Varga, A.; Molnár, J. 2006: Interaction between doxorubicin and the resistance modifier stilbene on multidrug resistant mouse lymphoma and human breast cancer cells Anticancer Research 26(5a): 3541-3546
Molnar, J.; Molnar, A.; Mucsi, I.; Pinter, O.; Nagy, B.; Varga, A.; Motohashi, N. 2003: Reversal of multidrug resistance in mouse lymphoma cells by phenothiazines In Vivo 17(2): 145-149
Qi, S.-N.; Song, L.-J.; Chen, Y.; Jing, Y.-X. 2010: Reversal of mdr1-mediated multidrug resistance in human leukemia cells by a new spin-labeled derivative of podophyllotoxin Die Pharmazie 65(2): 117-121
Xu, H.-B.; Li, L.; Liu, G.-Q. 2009: Reversal of P-glycoprotein-mediated multidrug resistance by guggulsterone in doxorubicin-resistant human myelogenous leukemia (K562/DOX) cells Die Pharmazie 64(10): 660-665
Bellamy, W.T.; Dalton, W.S.; Kailey, J.M.; Gleason, M.C.; McCloskey, T.M.; Dorr, R.T.; Alberts, D.S. 1988: Verapamil reversal of doxorubicin resistance in multidrug-resistant human myeloma cells and association with drug accumulation and DNA damage Cancer Research 48(22): 6365-6370
Leyland-Jones, B.R.; Townsend, A.J.; Tu, C.P.; Cowan, K.H.; Goldsmith, M.E. 1991: Antineoplastic drug sensitivity of human MCF-7 breast cancer cells stably transfected with a human alpha class glutathione S-transferase gene Cancer Research 51(2): 587-594
Mace, K.; Seif, I.; Anjard, C.; De Maeyer-Guignard, J.; Dodon, M.D.; Gazzolo, L.; De Maeyer, E. 1991: Enhanced resistance to HIV-1 replication in U937 cells stably transfected with the human IFN-beta gene behind an MHC promoter fragment Journal of Immunology 147(10): 3553-3559
Wang, Z.-r.; Bai, F.; Zhang, X.-y.; Wu, J.-m.; Guo, L.; Li, Z.; Feng, M. 2017: GGi as a gene carrier delivering MDR1 siRNA to A549/DDP cells for reversal of multidrug resistance Yao Xue Xue Bao 52(2): 309-317
Almquist, K.C.; Loe, D.W.; Hipfner, D.R.; Mackie, J.E.; Cole, S.P.; Deeley, R.G. 1995: Characterization of the M(r) 190,000 multidrug resistance protein (MRP) in drug-selected and transfected human tumor cell Cancer Research 55(1): 102-110
Fu, J.; Chen, Z.; Cen, J.; Ruan, C. 2000: Expression of the human multidrug resistance gene mdr1 in leukemic cells and its application in studying P-glycoprotein antagonists Chinese Medical Journal 113(3): 228-231
Funato, T. 1997: Reversal of drug resistance in human cancer cells by anti-oncogenes Gan to Kagaku Ryoho. Cancer and ChemoTherapy 24(4): 395-400
Yu, G.; Shu, R.; Sun, Y.; Cheng, L.; Song, Z.-C.; Zhang, X.-L. 2008: Experimental study on human periodontal ligament cells transfected with human amelogenin gene Shanghai Kou Qiang Yi Xue 17(1): 40-44
Schurr, E.; Raymond, M.; Bell, J.C.; Gros, P. 1989: Characterization of the multidrug resistance protein expressed in cell clones stably transfected with the mouse mdr1 cDNA Cancer Research 49(10): 2729-2733
Gao, Z.; Gao, Z.; Fields, J.Z.; Boman, B.M. 1998: Co-transfection of MDR1 and MRP antisense RNAs abolishes the drug resistance in multidrug-resistant human lung cancer cells Anticancer Research 18(4c): 3073-3076
Lo Muzio, L.; Staibano, S.; Pannone, G.; Mignogna, M.D.; Serpico, R.; Rubini, C.; Fioroni, M.; Fanali, S.; Piattelli, A. 2000: The human multidrug resistance gene (MDR-1): immunocytochemical detection of its expression in oral SCC Anticancer Research 20(5a): 2891-2897
Pan, L.; Tong, Y.; Zhou, S.; Wu, Y.; Mao, N.; Yang, X. 2000: Chemoprotection of transfer of multidrug resistance gene into human hematopoietic progenitor cell Chinese Medical Journal 113(6): 536-539
He, F.; Yang, Z.; Tan, Y. 2007: Odontogenesis of Delta1 gene transfected human dental pulp stem cells Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 21(10): 1133-1136
Kriukova, I.N.; Lushnikova, A.A.; Makhov, P.B.; Malivanova, T.F.; Laktionov, K.P. 2001: An antigen related to the mouse mammary cancer virus env gene product, detected in human lymphocytes, is associated with human breast cancer Molekuliarnaia Genetika Mikrobiologiia i Virusologiia 2: 37-41
Zhang, M-sheng.; Zhou, Y-feng.; Zhang, W-jie.; Zhang, X-lian.; Pan, Q.; Ji, X-mei.; Luo, Z-guo.; Wu, J-ping. 2006: Apoptosis induced by short hairpin RNA-mediated STAT6 gene silencing in human colon cancer cells Chinese Medical Journal 119(10): 801-808
Su, C-Cheng.; Chen, G-Wei.; Tan, T-Wei.; Lin, J-Gung.; Chung, J-Gung. 2006: Crude extract of garlic induced caspase-3 gene expression leading to apoptosis in human colon cancer cells In Vivo 20(1): 85-90