Pharmacological studies of sulbactam and its association with semisynthetic beta-lactam antibiotics
Nechifor, M.; Buiuc, D.; Diaconu, E.; Poiată, A.; Teslariu, E.; Filip, C.; Negru, A.; Antonescu, C.
Revista Medico-Chirurgicala a Societatii de Medici Si Naturalisti Din Iasi 96(1-2): 51-55
1992
ISSN/ISBN: 0048-7848 PMID: 1410925 Document Number: 4453
The acute toxicity, local tolerance and pharmacokinetic properties of sulbactame manufactured by the Iaşi Antibiotic Investigation Centre, alone or in association with ampicillin or amoxicillin were tested. Some tests were made comparatively with the product Unasyn--Pfizer. The obtained data show that this beta-lactamase inhibitor has a low toxicity--DL50 i.p. in mice over 4,000 mg/kg, both alone or associated with the two semisynthetic beta-lactamic antibiotics. The local tolerance is good and the serum levels of the above mentioned associations are above towards the tested bacteria and are similar or very close to those of Unasyn. It is believed that the therapeutical use of the association sulbactame + ampicillin or sulbactame + amoxicillin is very useful in the beta-lactamase producing germs infection.
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