Studies on the synthetic methods of 4-unsubstituted monocyclic beta-lactam antibiotics
Dong, Q.; Liu, D.F.
Yao Xue Xue Bao 22(1): 19-22
1987
ISSN/ISBN: 0513-4870 PMID: 3604688 Document Number: 301839
The key intermediate of monocyclic beta-lactams, N-benzyloxycarbonyl-3 S-amino-2-oxoazetidine (III), was synthesized from L-(+)-2,3-diaminopropanoic acid(I) by Ph3P.sbd.(PyS)2.sbd.CH3CN system and N-benzyloxycarbonylation. I was prepared from L(+)-aspartic acid by Schmidt rearrangement. Three derivatives (VIIIa .apprx. c) of this monocyclic beta-lactam were prepared and their biological activities evaluated.