Mechanisms of resistance to beta-lactam antibiotics
Wiedemann, B.; Tolxdorff-Neutzling, R.M.
Chemioterapia International Journal of the Mediterranean Society of ChemoTherapy 4(1): 24-27
1985
ISSN/ISBN: 0392-906X PMID: 3986943 Document Number: 248406
The complex mechanism of resistance towards beta-lactam antibiotics in Gram-negative bacteria can be described by a simple equation in which the hydrolytic activity of the enzyme, the affinity to the penicillin binding protein in competition to the affinity to the beta-lactamase, the quantity of the enzyme and the ability of the drug to penetrate the outer membrane are considered. Depending on the characteristics of the drug, the beta-lactamase, and the microorganisms, the hydrolysis of the drug, its binding, or the reduced penetration can be the predominant factors.