Phase i evaluation of beta-2'-deoxythioguanosine in pediatric patients with leukemia
Higgins, G.R.; Jamin, D.C.; Shore, N.A.; Momparler, R.; Hartman, G.; Siegel, S.E.
Cancer Treatment Reports 69(6): 699-701
1985
ISSN/ISBN: 0361-5960 PMID: 3860294 Document Number: 4454
Thirty-one pediatric patients with acute leukemia who had relapsed on either 6-mercaptopurine or 6-thioguanine were treated with beta-2'-deoxythioguanosine, which was administered as an iv infusion every 12 hours for three or six doses every 2 weeks. Severe nausea and vomiting and urate nephropathy were the dose-limiting toxic effects. Therapeutic responses occurred in four of 24 children with acute lymphocytic leukemia and in two of seven with acute nonlymphoblastic leukemia.
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