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Origin of sequence specific cleavage of DNA by bleomycins

Kuroda, R.; Shinomiya, M.; Otsuka, M.

Nucleic Acids Symposium Series 27: 9-10

1992

ISSN/ISBN: 0261-3166
PMID: 1283919
Document Number: 395196
A new DNA photocleaving agent which contains bleomycin A2's DNA binding portion and its mono- and terthiazole analogues have been designed and synthesized, and their DNA binding mode and cleavage base specificity have been studied. The photoactive p-nitrobenzoyl group attached at the end of molecules cleaves DNA on UV irradiation. All the oligo-thiazole compounds exhibited high sequence specificity in DNA scission. The bithiazole derivative did not cleave DNA at or near 5'-GpT-3' or 5'-GpC-3' as expected from widely believed DNA binding mechanism of the antibiotics.

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Iwaniec, L.M.; Kroll, J.J.; Roethel, W.M.; Maybaum, J. 1991: Selective inhibition of sequence-specific protein-DNA interactions by incorporation of 6-thioguanine: cleavage by restriction endonucleases Molecular Pharmacology 39(3): 299-306
Mirabelli, C.K.; Ting, A.; Huang, C.H.; Mong, S.; Crooke, S.T. 1982: Bleomycin and talisomycin sequence-specific strand scission of DNA: a mechanism of double-strand cleavage Cancer Research 42(7): 2779-2785
Sovová, V.; Trávnícek, M.; Hlozánek, I.; Cerná, H.; Sulová, A. 1984: Analysis of gag-myc proteins of partially transformation-defective mutants of avian myelocytomatosis virus strain MC29 by in vitro cleavage with protease p15: indication for the presence of specific cleavage site p15 in the myc domain of fusion protein Folia Biologica 30(3): 145-151
Mostov, K.E.; Defoor, P.; Fleischer, S.; Blobel, G. 1981: Co-translational membrane integration of calcium pump protein without signal sequence cleavage Nature 292(5818): 87-88
De Isabella, P.; Capranico, G.; Palumbo, M.; Sissi, C.; Krapcho, A.P.; Zunino, F. 1993: Sequence selectivity of topoisomerase II DNA cleavage stimulated by mitoxantrone derivatives: relationships to drug DNA binding and cellular effects Molecular Pharmacology 43(5): 715-721
Shirakura, H.; Hosono, K.; Kawai, G.; Takai, K.; Ohtsuki, T.; Watanabe, K.; Sakamoto, K.; Yokoyama, S.; Takaku, H. 1997: Study on site specific cleavage of RNA Nucleic Acids Symposium Series 37: 217-218
Nishio, H.; Matsui, H.; Etoh, S.; Moia, L.J.; Tokuda, M.; Itano, T.; Hatase, O. 1992: Identification of testis specific calcineurin beta subunit isoform by a monoclonal antibody and detection of a specific six amino acid sequence Biochemical and Biophysical Research Communications 182(1): 34-38
Hwang, L.H.; Lin, Y.J.; Lai, W.C.; Lo, M.S. 1991: Protease-like sequence in hepatitis B virus core antigen is not involved in the cleavage processes of core protein in Escherichia coli Zhonghua Minguo Wei Sheng Wu Ji Mian Yi Xue Za Zhi 24(1): 71-83
Nakamura, T.; Dohno, C.; Nakatani, K.; Saito, I. 1997: -GG- specific cleavage via hole hopping through double-stranded DNA Nucleic Acids Symposium Series 37: 87-88
Grokhovskiĭ, S.L.; Nikolaev, V.A.; Zubarev, V.E.; Surovaia, A.N.; Zhuze, A.L.; Chernov, B.K.; Sidorova, N.I.; Zasedatelev, A.S.; Gurskiĭ, G.V. 1992: Specific DNA cleavage by an analog of netropsin containing a copper(II) chelating peptide Gly-Gly-His Molekuliarnaia Biologiia 26(6): 1274-1297
Grokhovskiĭ, S.L.; Nikolaev, V.A.; Gottikh, B.P.; Zhuze, A.L. 2002: Ligands with specific affinity to a specific sequence of DNA base pairs. XI. the synthesis and binding to DNA of bis-netropsins with the C-ends of their netropsin fragments tethered by tetra- or pentamethylene linkers Bioorganicheskaia Khimiia 28(6): 502-517
Matsugo, S.; Saito, I. 1990: Photoinduced DNA cleavage by naphthalimide hydroperoxide-specific strand scission at -GG- site of DNA Nucleic Acids Symposium Series 22: 57-58
Garten, W.; Vey, M.; Ohuchi, R.; Ohuchi, M.; Klenk, H.D. 1991: Modification of the cleavage activation of the influenza virus hemagglutinin by site-specific mutagenesis Behring Institute Mitteilungen 89: 12-22
Bugreev, D.V.; Buneva, V.N.; Nevinskiĭ, G.A. 2003: The mechanism of specific cleavage of supercoiled DNA by human DNA topoisomerase I: the effect of ligand structure on the catalytic step of reaction Molekuliarnaia Biologiia 37(2): 325-339
Hay, R.T. 1985: The origin of adenovirus DNA replication: minimal DNA sequence requirement in vivo EMBO Journal 4(2): 421-426
Feng, Q.; Sun, B.; Zhao, Y. 2000: Study on the in vitro cleavage abilities of ribozymes specific to different sites of bcr-abl fusion gene and their induction of apoptosis in K562 cells Zhonghua Yi Xue Za Zhi 80(2): 127-130
Pansevich, L.I.; Barkovskiĭ, E.V. 1990: Prediction of the secondary structure of calmodulins of various origin by their amino acid sequence Biofizika 35(5): 786-789
Bao, J.-y.; Zhao, W.-j.; Li, L.; Wang, Z.-l.; Wu, G.-z.; Wu, X.-d.; Liu, C.-j.; Wang, Q.-h.; Wang, J.-w.; Liu, Y.-t.; Li, J.-m.; Wang, Y.-l. 2011: Sequence analysis of the phosphoprotein gene of peste des petits ruminants virus of Chinese origin Bing du Xue Bao 27(1): 26-33
Wan, C.-H.; Fu, G.-H.; Cheng, L.-F.; Shi, S.-H.; Chen, H.-M.; Peng, C.-X.; Lin, F.; Lin, J.-S.; Huang, Y. 2012: Sequence comparison of the hemagglutinin gene of the duck-origin H9N2 subtype avian influenza viruses Bing du Xue Bao 28(2): 158-164
Gubler, M.L.; Abarzúa, P. 1995: Nonradioactive assay for sequence-specific DNA binding proteins Biotechniques 18(6): 1008 1011-4