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The mechanism of specific cleavage of supercoiled DNA by human DNA topoisomerase I: the effect of ligand structure on the catalytic step of reaction

Bugreev, D.V.; Buneva, V.N.; Nevinskiĭ, G.A.

Molekuliarnaia Biologiia 37(2): 325-339

2003

ISSN/ISBN: 0026-8984
PMID: 12723479
Document Number: 562524
Eukaryotic DNA topoisomerase I (Topo) regulates the topological state of cell DNA and plays an important part in replication, transcription, repair, and recombination. Factors affecting the specific recognition of topologically stressed DNA were analyzed on the basis of the thermodynamic and kinetic data on the Topo-DNA interaction and the X-ray data on human Topo. A model was advanced for possible structural changes occurring in the ligand after initial recognition. The effect of conformational changes in specific DNA on the catalytic stage of the reaction was analyzed.

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Husain, I.; Mohler, J.L.; Seigler, H.F.; Besterman, J.M. 1994: Elevation of topoisomerase I messenger RNA, protein, and catalytic activity in human tumors: demonstration of tumor-type specificity and implications for cancer chemotherapy Cancer Research 54(2): 539-546
Shimayama, T.; Sawata, S.; Komiyama, M.; Takagi, Y.; Tanaka, Y.; Wada, A.; Sugimoto, N.; Rossi, J.J.; Nishikawa, F.; Nishikawa, S. 1992: Substitution of non-catalytic stem and loop regions of hammerhead ribozyme with DNA counterparts only increases KM without sacrificing the catalytic step (kcat): a way to improve substrate-specificity Nucleic Acids Symposium Series 27: 17-18
Sansom, M.S.; Babu, Y.S.; Hajdu, J.; Stuart, D.I.; Stura, E.A.; Johnson, L.N. 1984: The role of pyridoxal phosphate in glycogen phosphorylase b; structure, environment and relationship to catalytic mechanism Progress in Clinical and Biological Research 144a: 127-146
Mirabelli, C.K.; Ting, A.; Huang, C.H.; Mong, S.; Crooke, S.T. 1982: Bleomycin and talisomycin sequence-specific strand scission of DNA: a mechanism of double-strand cleavage Cancer Research 42(7): 2779-2785
Ito, K.; Tanokura, M. 2008: Structure and reaction mechanism of azoreductase Seikagaku. Journal of Japanese Biochemical Society 80(6): 550-559
Shaduri, M.I.; Polianovskiĭ, O.L. 1975: The effect of various acylating agents on the catalytic properties and structure of aspartate aminotransferase Molekuliarnaia Biologiia 9(3): 468-478
Barra, D.; Martini, F.; Bannister, W.H.; Bannister, J.V.; Rotilio, G.; Bossa, F. 1982: The primary structure of human erythrocyte copper/zinc superoxide dismutase: cleavage with trypsin and chymotrypsin Italian Journal of Biochemistry 31(1): 28-38
Herzog, C.E.; Holmes, K.A.; Tuschong, L.M.; Ganapathi, R.; Zwelling, L.A. 1998: Absence of topoisomerase IIbeta in an amsacrine-resistant human leukemia cell line with mutant topoisomerase IIalpha Cancer Research 58(23): 5298-5300
Sovová, V.; Trávnícek, M.; Hlozánek, I.; Cerná, H.; Sulová, A. 1984: Analysis of gag-myc proteins of partially transformation-defective mutants of avian myelocytomatosis virus strain MC29 by in vitro cleavage with protease p15: indication for the presence of specific cleavage site p15 in the myc domain of fusion protein Folia Biologica 30(3): 145-151
De Isabella, P.; Capranico, G.; Palumbo, M.; Sissi, C.; Krapcho, A.P.; Zunino, F. 1993: Sequence selectivity of topoisomerase II DNA cleavage stimulated by mitoxantrone derivatives: relationships to drug DNA binding and cellular effects Molecular Pharmacology 43(5): 715-721
Panfilov, V.E. 1970: Biomechanical parameters of human gait. 1. time structure of the step Biofizika 15(5): 927-931
Zwelling, L.A.; Estey, E.; Silberman, L.; Doyle, S.; Hittelman, W. 1987: Effect of cell proliferation and chromatin conformation on intercalator-induced, protein-associated DNA cleavage in human brain tumor cells and human fibroblasts Cancer Research 47(1): 251-257
Harker, W.G.; Slade, D.L.; Parr, R.L.; Feldhoff, P.W.; Sullivan, D.M.; Holguin, M.H. 1995: Alterations in the topoisomerase Ii alpha gene, messenger RNA, and subcellular protein distribution as well as reduced expression of the DNA topoisomerase Ii beta enzyme in a mitoxantrone-resistant HL-60 human leukemia cell line Cancer Research 55(8): 1707-1716
Sehested, M.; Wessel, I.; Jensen, L.H.; Holm, B.; Oliveri, R.S.; Kenwrick, S.; Creighton, A.M.; Nitiss, J.L.; Jensen, P.B. 1998: Chinese hamster ovary cells resistant to the topoisomerase Ii catalytic inhibitor ICRF-159: a Tyr49Phe mutation confers high-level resistance to bisdioxopiperazines Cancer Research 58(7): 1460-1468
Elnemr, A.; Ohta, T.; Yachie, A.; Kayahara, M.; Kitagawa, H.; Ninomiya, I.; Fushida, S.; Fujimura, T.; Nishimura, G.; Shimizu, K.; Miwa, K. 2001: Human pancreatic cancer cells express non-functional Fas receptors and counterattack lymphocytes by expressing Fas ligand; a potential mechanism for immune escape International Journal of Oncology 18(1): 33-39
Belew, M.; Porath, J. 1990: Immobilized metal ion affinity chromatography. Effect of solute structure, ligand density and salt concentration on the retention of peptides Journal of Chromatography 516(2): 333-354
Bobrovnik, S.A. 2000: Determination of the concentration of ligand-specific molecules, found in mixtures with ligand-nonspecific molecules Ukrains'kyi Biokhimichnyi Zhurnal 72(1): 113-119
Zhou, S.; Mao, N.; Zhao, M. 1998: Effect of recombinant human FLT3 ligand (rhFL) on in vitro expansion of human cord blood CD34+ cells Zhonghua Yi Xue Za Zhi 78(1): 37-39
Kim, D.; Lee, I.S.; Jung, J.H.; Lee, C.O.; Choi, S.U. 1999: Psammaplin A, a natural phenolic compound, has inhibitory effect on human topoisomerase Ii and is cytotoxic to cancer cells Anticancer Research 19(5b): 4085-4090
Küllertz, G.; Fischer, G.; Barth, A. 1978: Catalytic mechanism of dipeptidyl-peptidase IV Acta Biologica et Medica Germanica 37(4): 559-567