Biochemical indicators of anthracycline sensitivity of blast cells from patients with hemoblastoses
Sidorova, T.A.; Gerasimova, G.K.; Lepkov, S.V.; Volkova, M.A.
Antibiotiki i Khimioterapiia 37(5): 17-20
1992
ISSN/ISBN: 0235-2990 PMID: 1417322 Document Number: 392823
It was shown that accumulation of adriamycin (ADR) and its impact on DNA synthesis in the blast cells of patients with hemoblastosis studied under conditions of short-term incubation correlated with the antileukemic activity of anthracyclines. The combination of the two biochemical and pharmacological indices, i.e. the high levels of ADR accumulation and inhibition of DNA synthesis, is may useful in solving the problem on inclusion of the antibiotics to the schemes of combined chemotherapy of patients with hemoblastosis.