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Certain biochemical features of leukocytes in blast crisis of chronic myelogenous leukemia

Kharchenko, M.F.; Rybakova, L.P.; Filanovskaia, L.I.; Saltykova, L.B.; Bitiukova, E.S.; Shcherbakova, E.G.; Rukavitsyn, O.A.; Bessmel'tsev, S.S.; Abdulkadyrov, K.M.; Blinov, M.M.

Voprosy Meditsinskoi Khimii 44(3): 274-280

1998

ISSN/ISBN: 0042-8809
PMID: 9703628
Document Number: 485972
The content of nuclear high mobility group (HMG) proteins, activities of ornithine decarboxylase (ODC), adenosine deaminase (ADA) and purine nucleoside phosphorylase (PNP) and also glycosaminoglycan (GAG) content and composition were studied in leukocytes of patients with chronic myelogenous leukemia in the phase of blast crisis (BC CML). Myeloid and lymphoid cytochemical variants of BC CML differ by biochemical parameters. It is suggested, that the content of HMG-proteins, activities of ODC and PNP, and electrophoretic patterns of GAGs could be used in diagnostics of two main variants of BC CML.

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