Chronic myelogenous leukemia with blastic crisis in which expression of P-glycoprotein was associated with resistance to chemotherapy
Utsunomiya, A.; Kuwazuru, Y.; Chuman, Y.; Mishige, Y.; Saito, T.; Terada, A.; Iwahashi, M.; Hanada, S.; Yoshimura, A.; Akiyama, S.
Gan to Kagaku Ryoho. Cancer and ChemoTherapy 19(11): 1915-1918
1992
ISSN/ISBN: 0385-0684 PMID: 1355642 Document Number: 400159
A 55-year-old woman with chronic myelogenous leukemia developed a lymphoid blast crisis (BC) 10 months after diagnosis. By using immunoblotting with a monoclonal antibody against P-glycoprotein (P-gp) C219, her leukemia cells from the first and 3rd crises were shown to be negative for the P-gp, while the cells of the 4th crisis were detected to have a high level of P-gp. This patient did not respond to chemotherapy with several anti-cancer agents in the 4th crisis, although complete remission was achieved in the first, second and third crises after administration of agents including vincristine and prednisolone. Therefore the expression of P-gp in the 4th BC might have been closely related to the resistance to chemotherapy.