Does blastic crisis as revealed in chronic myeloid leukemia simulate either acute primary leukemia or acute primary leukemia with Philadelphia chromosome?
Misset, J.L.; Venuat, A.M.; Nevarez, L.; Mathé, G.
La Nouvelle Presse Medicale 6(27): 2409-2413
1977
ISSN/ISBN: 0301-1518 PMID: 268605 Document Number: 119805
In ten cases of apparently primary acute leukaemia, the discovery of a Philadelphia chromosome at routine examination of the caryotype led a diagnosis of blastic crisis of chronic myeloid leukemia. The clinical, cytological and cytogenetic pictures varied and only routine caryotypic examination may be used in reaching the diagnosis. The prognosis appear to be less bad than in blastic crises occurring after a long course of chronic myeloid leukaemia and closer to that of primary acute myeloid leukaemia.