Treatment of myeloid blastic crisis of chronic myelogenous leukemia
Preisler, H.D.; Raza, A.; Higby, D.; Kirshner, J.; Woll, J.; Bennett, J.; Winton, L.; Weiner, R.; Richman, C.; Golomb, H.
Cancer Treatment Reports 68(11): 1351-1355
1984
ISSN/ISBN: 0361-5960 PMID: 6388833 Document Number: 228267
Patients with myeloid blastic crisis of chronic myelogenous leukemia were treated by chemotherapy [cytoarabine, doxorubicin, prednisone, vincristine, busulfan] or by autologous hematpoietic reconstitution after aggressive chemotherapy. Chemotherapy alone failed to produce a 2nd chronic phase. Autologous transplantation resulted in the establishment of a 2nd chronic phase in 2 of 10 patients treated with a 4-drug regimen; treatment with high-dose cytarabine with or without busulfan resulted in the establishment of a 2nd chronic phase in 3 of 6 patients and the return of normal hematopoiesis in a 4th. Consolidation chemotherapy appeared to be beneficial.