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Squamous carcinoma of oral tongue: prognostic significance of flow-cytometric DNA content

Gomez, R.; el-Naggar, A.K.; Byers, R.M.; Garnsey, L.; Luna, M.A.; Batsakis, J.G.

Modern Pathology An Official Journal of the United States and Canadian Academy of Pathology Inc 5(2): 141-145

1992

ISSN/ISBN: 0893-3952
PMID: 1574491
Document Number: 392822
Thirty-eight squamous carcinomas of the mobile tongue were flow cytometrically analyzed for their DNA content, and the results correlated with clinicopathologic parameters and patient survival. Tumor size (p = 0.01), depth of invasion (p = 0.05), histologic differentiation (p = 0.03), ploidy pattern (p = 0.01), and S-phase (p = 0.001) showed significant correlation with patients' clinical outcomes in univariate analyses. A multifactorial regression analysis of all significant parameters indicated that S-phase percentage and depth of tumor invasion were independent prognostic factors in this cohort.

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