Expression and significance of P75 neurotrophin receptor in oral squamous cell carcinoma
Wu, X.-y.; Tong, D.-d.; Zhang, F.-h.
Shanghai Kou Qiang Yi Xue 20(4): 405-408
2011
ISSN/ISBN: 1006-7248 PMID: 21909608 Document Number: 650186
To investigate the expression of P75NTR in oral squamous cell carcinoma and evaluate the possibilities of P75NTR as a prognostic indicator of oral squamous cell carcinoma as well as a marker of cancer stem cell. SP immunohistochemical method was used to detect the expressions of tongue squamous cell carcinoma line Tca8113 and 43 surgically resected squamous cell carcinoma tissues. Five peri-carcinoma tissues and 8 normal tissues were selected as control. SPSS16.0 software package was applied for X(2) test. P75NTR was positive in the Tca8113 cell line and located in the cell membrane. Thirty-three cases of the 43 OSCC patients showed positive expression of P75NTR. Para-carcinoma tissues and normal tissues showed negative expression of P75NTR. Positive P75NTR located in the cell membrane and dispersed in the cancer nest, and had a trend of cluster distribution. The expression of P75NTR had a relationship with tumor clinical stage(P<0.05) and lymph node metastasis(P<0.05). The expression of P75NTR can predict the prognosis of oral squamous cell carcinoma, yet it can not be taken as a marker of cancer stem cell alone. Further study should be taken to investigate the role and mechanism of P75NTR in the development of tumor.