Flow cytometric analysis of DNA content in focal nodular hyperplasia and hepatocellular carcinoma
Kopper, L.; Lapis, K.; Schaff, Z.; Mihalik, R.; Karácsony, S.; Szécsény, A.
Neoplasma 38(3): 257-263
1991
ISSN/ISBN: 0028-2685 PMID: 1649974 Document Number: 369125
DNA index of twenty-three surgically removed, formalin-fixed and paraffin-embedded liver specimens (10 focal nodular hyperplasias - FNH, and 13 hepatocellular carcinomas - HCC) were studied by flow cytometry. Diploid value appeared in 9/10 FNH (one was hypodiploid), while 10/13 HCC (77%) had DNA aneuploidy (one hypo- and 9 hyperdiploid). The presence of normal DNA content in 3 HCCs suggests that DNA aneuploidy only cannot indicate the malignant transformation of a benign lesion (e.g. FNH).