Focal nodular hyperplasia of the liver and contraceptive steroids
St Omer, F.B.; Iozzo, R.V.; Casetti, P.; Dellarolle, A.C.
Acta Hepato-Gastroenterologica 25(4): 319-321
1978
ISSN/ISBN: 0300-970X PMID: 696209 Document Number: 127398
A case of focal nodular hyperplasia (FNH) of the liver in a 25-year-old woman taking oral contraceptives is reported. The patient had taken Lyndiol for 6 months (1975) and had received 6 injections of 5 mg benzoate estradiol plus 50 mg progesterone at intervals of about 2 months (January 1974-February 1976). An isolated mass was found in the right hepatic lobe. The microscopic findings corresponded to FNH. The vascular alterations consisted of a marked increase of arterial and venous formations, intimal proliferation, diffused thrombosis, and the presence of large blood spaces. The possibility that these vascular alterations be the real effect of steroid hormones on a preexistent hepatic lesion should not be excluded.