The effect of hydrocortisone on the activity of the alkaline proteinase systems in the rat thymus
Ogurtsov, S.I.; Dukhanin, A.S.; Sergeev, P.V.; Eĭiubova, A.A.
Farmakologiia i Toksikologiia 54(2): 52-54
1991
ISSN/ISBN: 0014-8318 PMID: 1884798 Document Number: 385514
The effect of single and chronic administration of hydrocortisone on the thymus proteinase activity in the alkaline pH range was studied on rats. The presence in the thymus of the glucocorticoid-sensitive alkaline proteinase system induced by hydrocortisone was shown. A decrease of the activity of the system in the adrenalectomized animals was found. The possible relationship between the thymolytic effects of hydrocortisone and the increased activity of the alkaline proteinase systems of the thymus is concluded.