Hydrocortisone action on the thiol groups of the thymus
Toma, V.; Fabian, N.; Crivii, M.S.
Endocrinologie 24(4): 253-255
1986
ISSN/ISBN: 0253-1801 PMID: 3809967 Document Number: 268566
The total (T) proteic (P) and non proteic (NP)-SH groups in the thymus of male Wistar rats were assayed and the P/NP ratio calculated. Hydrocortisone was administered to the experimental groups as follows: 1, 6, 15 and 45 mg/100 g body weight. Up to a dose of 6 mg HC, the thiol groups decrease progressively, especially the NP groups. At higher doses, the first two.sbd.SH groups (T and P) continue to decrease quantitatively, whereas the NP thiol groups notably increase. In the author's opinion, this is due to the exacerbating stages encountered during stress.