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Changes of the concentration of lipid peroxidation products and thiol groups in rat brains with long-term intoxication with methanol

Barzdo, M.; Gloc, E.; Meissner, E.; Jurczyk, A.P.; Jankowska, B.; Berent, Jław.; Szram, S.

Archiwum Medycyny Sadowej i Kryminologii 55(1): 39-41

2005

ISSN/ISBN: 0324-8267
PMID: 15984119
Document Number: 592428
The aim of this paper was to define the influence of long-term methanol intoxication on the changes of end products of lipid peroxidation, reacting with thiobarbituric acid (TBA-reactive products) and free SH-group concentration in rat brains. The experiment was conducted on male Lewis rats. The experimental groups received a 1-molar methanol solution and the control group received tap water. The animals were killed after 4, 8 and 12 weeks of intoxication and their brains were collected for further examination, which encompassed measurement of the concentration of TBA-reactive products and free SH-groups. The revealed changes of TBA-reactive products and free SH-group concentration were not statistically significant.

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