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Protection from foot-and-mouth disease virus in naturally-susceptible animals by a linear polymer of a synthetic peptide

Pavlov, A.V.; Rybakov, S.S.; Ivaniushchenkov, V.N.; Chepurkin, A.V.; Petrov, V.N.; Driagalin, N.N.; Burdov, A.N.

Bioorganicheskaia Khimiia 17(7): 953-963

1991

ISSN/ISBN: 0132-3423
PMID: 1665331
Document Number: 383525
Linear polymer of a peptide corresponding to the fragment 142-155 of the foot-and-mouth disease virus A22(550) protein (VP1) was synthesized. Whereas the monomeric peptide was only slightly immunogenic, the polymer induced virus-neutralizing antibodies in rabbits and protected 100% guinea pigs. Sheep vaccinated once and cattle vaccinated twice were stable against infection with the homologous virulent foot-and-mouth disease virus.

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