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Synthetic immunogenic complexes containing a peptide from the surface protein of the foot-and-mouth disease virus

Rar, V.A.; Makarov, E.A.; Iurovskiĭ, V.V.; Meshcheriakova, E.A.; Andronova, T.M.; Ivanov, V.T.

Bioorganicheskaia Khimiia 16(7): 904-915

1990

ISSN/ISBN: 0132-3423
PMID: 2173604
Document Number: 360229
Synthetic constructions containing a peptide antigenic determinant (C-terminal peptide 205-213 of the surface VP1 protein of the foot-and-mouth disease virus, O1K strain), glucosaminylmuramayl dipeptide (GMDP), and polyionic synthetic carriers were prepared. The polymerized peptide and peptide-BSA conjugates were synthesized as well. Among the constructions obtained only peptide-BSA conjugate proved to be highly immunogenic. Application of synthetic constructions to design immunogenic complexes is discussed.

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