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Protection against foot-and-mouth disease by immunization with a chemically synthesized peptide predicted from the viral nucleotide sequence

Bittle, J.L.; Houghten, R.A.; Alexander, H.; Shinnick, T.M.; Sutcliffe, J.G.; Lerner, R.A.; Rowlands, D.J.; Brown, F.

Nature 298(5869): 30-33

1982

ISSN/ISBN: 0028-0836
PMID: 7045684
Document Number: 186375
Chemically synthesized peptides corresponding to 2 different regions of the VP1 polypeptide of foot-and-mouth disease virus (FMDV) produced high levels of serotype-specific virus neutralizing antibody in cattle, guinea pigs and rabbits. A single inoculation of 1 of these peptides protected guinea pigs against subsequent challenge with the virulent virus.

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