Identification of a protective epitope--a fragment of Lassa virus nucleoprotein
Moshnikova, A.B.; Kozhich, A.T.; Kras'ko, A.G.; Chikin, L.D.; Barkar, N.D.; Ivanov, V.T.
Bioorganicheskaia Khimiia 17(4): 572-573
1991
ISSN/ISBN: 0132-3423 PMID: 1716105 Document Number: 378147
Several peptides from Lassa virus glyco- and nucleoproteins were predicted as probable T-cell epitopes. Their synthesis was performed by solid phase method. The study of possible protective effect in vivo with Lassa-sensitive CBA mice revealed protective epitope within the 277-303 nucleoprotein region. Further studies reduced the protective epitope structure to the 287-300 nucleoprotein fragment.
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