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Immunization of rabbits with Lassa virus

Orlova, S.V.; Godneva, A.T.; Ignat'ev, G.M.; Bystrova, S.I.

Voprosy Virusologii 35(1): 59-61

1990

ISSN/ISBN: 0507-4088
PMID: 2363276
Document Number: 362009
The parameters of humoral and cell-mediated immunity after inoculation of the infectious and inactivated antigen of Lassa virus to rabbits which are insusceptible to this infection were studied. Lassa virus antigen was demonstrated to induce synthesis of specific antibodies in rabbits the level of which was proportional to the dose of inoculation and the time of immunization. The results of leukocyte blastogenesis test and delayed type hypersensitivity test confirm the development of sensitization to inactivated Lassa virus in immune rabbits.

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