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Toxic effects in rabbits after immunization against the pyrrolizidine alkaloid retrorsine

Leidinger, E.; Loupal, G.; Gutleb, R.; Miller, I.; Chizzola, R.

Deutsche Tierärztliche Wochenschrift 99(8): 332-335

1992

ISSN/ISBN: 0341-6593
PMID: 1425325
Document Number: 392436
Six rabbits were immunized against the pyrrolizidine alkaloid retrorsin, conjugated to bovine serum albumin. Seven i.v. inoculations were distributed over a period of half a year. The total antigen dose differed between animals. Towards the end of the experiment all animals (except 2 receiving the lowest antigen dose) suffered from apathy, anorexia and loss of body weight. Pathologically these symptoms correlated well with liver cirrhosis, gradually dependent on the total antigen dose. Blood-chemical parameters were disparate and contradictory.

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Yan, C.C.; Huxtable, R.J. 1995: Effects of the pyrrolizidine alkaloid, retrorsine, on sulfur metabolism, in the liver Proceedings of the Western Pharmacology Society 38: 37-40
Chesney, C.F.; Hsu, I.C.; Allen, J.R. 1974: Modifications of the in vitro metabolism of the hepatotoxic pyrrolizidine alkaloid, monocrotaline Research Communications in Chemical Pathology and Pharmacology 8(3): 567-570
Winter, H.; Seawright, A.A.; Noltie, H.J.; Mattocks, A.R.; Jukes, R.; Wangdi, K.; Gurung, J.B. 1994: Pyrrolizidine alkaloid poisoning of yaks: identification of the plants involved Veterinary Record 134(6): 135-139
Williams, D.E.; Reed, R.L.; Kedzierski, B.; Dannan, G.A.; Guengerich, F.P.; Buhler, D.R. 1989: Bioactivation and detoxication of the pyrrolizidine alkaloid senecionine by cytochrome P-450 enzymes in rat liver Drug Metabolism and Disposition: the Biological Fate of Chemicals 17(4): 387-392
Seawright, A.A.; Hrdlicka, J.; Wright, J.D.; Kerr, D.R.; Mattocks, A.R.; Jukes, R. 1991: The identification of hepatotoxic pyrrolizidine alkaloid exposure in horses by the demonstration of sulphur-bound pyrrolic metabolites on their hemoglobin Veterinary and Human Toxicology 33(3): 286-287
Koni, I. 1988: Experimental IgA nephropathy in rabbits: effects of oral immunization in serum sickness nephritis Nihon Jinzo Gakkai Shi 30(1): 9-21
Matej, H.; Metzger, M.; Smogòr, W. 1973: Artificial immunization of rabbits against experimental syphilis. II. Immunological side effects of the treponemal vaccine Archivum Immunologiae et Therapiae Experimentalis 21(2): 263-270
Czajkowska, T.; Krysiak, B. 1987: Experimental studies of the toxic effects of 1,3,5-trioxane and 1,3-dioxolane. II. Cumulation of toxic effect Medycyna Pracy 38(4): 244-249
Czajkowska, T.; Krysiak, B.; Popińska, E. 1987: Experimental studies of toxic effects of 1,3,5-trioxane and 1,3-dioxolane. I. Acute toxic effect Medycyna Pracy 38(3): 184-190
Orlova, S.V.; Godneva, A.T.; Ignat'ev, G.M.; Bystrova, S.I. 1990: Immunization of rabbits with Lassa virus Voprosy Virusologii 35(1): 59-61
Hahn, J.; Aehnelt, E. 1972: Demonstration of toxic food constituents in experiments with rabbits Deutsche Tierärztliche Wochenschrift 79(7): 155-157
Krutitskaia, L.I.; Zhebrun, A.B. 1995: Autoimmune reactions in rabbits induced by immunization and hyperimmunization Zhurnal Mikrobiologii Epidemiologii i Immunobiologii 6: 50-51
Barbany, J.R.; Gras, J. 1978: Kinectics of IgM and IgG response in repeated immunization of rabbits with sheep erythrocytes Allergologia et Immunopathologia 6(6): 497-506
Peng, H-yan.; Zhang, Y-hong.; Han, Y.; Wang, M. 2005: Studies on the anticancer effects of total alkaloid from Viscum coloratum Zhongguo Zhong Yao Za Zhi 30(5): 381
Uhlír, J. 1992: Immunization of rabbits with antigens from Psoroptes cuniculi, the rabbit scab mite Folia Parasitologica 39(4): 375-382
Bednarík, T.; Cajthamlová, H. 1971: Formation of precipitins to albumin in normal and splenectomized rabbits during intravenous immunization Physiologia Bohemoslovaca 20(1): 39-42
Wang, J.-Y.; Liu, Z.-P.; Liu, L.; Liu, C. 2008: Effects of NaCl on the growth and alkaloid content of Catharanthus roseus seedlings Ying Yong Sheng Tai Xue Bao 19(10): 2143-2148
Andersen, R.A.; Burton, H.R.; Fleming, P.D.; Hamilton-Kemp, T.R.; Gay, S.L. 1987: Effects of air-curing environment on alkaloid-derived nitrosamines in burley tobacco IARC Scientific Publications 84: 451-455
Büschenfelde, K.H.; Kössling, F.K.; Miescher, P.A. 1972: Experimental chronic active hepatitis in rabbits following immunization with human liver proteins Clinical and Experimental Immunology 11(1): 99-108
Huard, M.I.; Siebeling, R.J. 1971: Depressed cellular and humoral hemolysin responses of rabbits injected intraperitoneally with mineral oil before immunization Journal of Immunology 106(1): 266-270