Synthesis of a new class of 1,4-dihydropyridines having a hydroxamic ester group in position 3 with a potential calcium antagonistic activity
Inglesi, M.; Nicola, M.; Magnetti, S.
Farmaco 45(12): 1327-1340
1990
ISSN/ISBN: 0014-827X PMID: 2090142 Document Number: 367514
The synthesis of new 1,4-dihydropyridines having a hydroxamic acid or hydroxamic ester group in position 3 is described. Pharmacological evaluation included calcium antagonistic activity in the guinea pig Taenia coli test and acute toxicity. The compounds had not a calcium antagonistic activity, if compared with other well known DHP utilized as standard, so the pharmacological tests were not furtherly studied.
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