Orientation of genes in the Bacillus subtilis chromosome
Zeigler, D.R.; Dean, D.H.
Genetics 125(4): 703-708
1990
ISSN/ISBN: 0016-6731 PMID: 2118869 Document Number: 363102
The orientation of 96 genes on the Bacillus subtilis chromosome was deduced by the analysis of published data. Of these genes, 91 were found to be oriented so that their promoters were proximal to the chromosomal replication origin and their transcription termini to the replication terminus. Transcription of these genes would therefore be co-directional with replication. This chromosomal organization is consistent with the hypothesis advanced for Escherichia coli that bacteria avoid head-on collisions between RNA polymerase and DNA replication proteins by the appropriate orientation of their transcription units.