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Serodiagnosis of human paragonimiasis caused by Paragonimus heterotremus

Pariyanonda, S.; Maleewong, W.; Pipitgool, V.; Wongkham, C.; Morakote, N.; Intapan, P.; Thirakharn, B.; Boonphadung, N.

Southeast Asian Journal of Tropical Medicine and Public Health 21(1): 103-107

1990

ISSN/ISBN: 0125-1562
PMID: 2402668
Document Number: 362409
Enzyme-linked immunosorbent assay (ELISA) and indirect hemagglutination tests (IHA) were evaluated for serodiagnosis of human paragonimiasis caused by Paragonimus heterotremus using homologous adult worm extract as antigen. IgG-ELISA was the most sensitive, being positive in all paragonimiasis sera tested while IHA and IgA-ELISA gave 88% and 59% positive rates respectively. Cross reactivity in IgG-ELISA was detected with fascioliasis sera, producing overall assay specificity of 97%. It is suggested that IgG-ELISA is a reliable serodiagnostic test for human paragonimiasis caused by Paragonimus heterotremus.

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