HIV-reverse transcriptase and human DNA polymerase alpha share amino acid sequence homologies to bacterial penicillin-binding proteins
Hafkemeyer, P.; Neftel, K.A.; Hübscher, U.
Methods and Findings in Experimental and Clinical Pharmacology 12(1): 43-46
1990
ISSN/ISBN: 0379-0355 PMID: 1690323 Document Number: 356126
Penicillin-binding proteins are the specific targets for the beta-lactam antibiotics. Recently it was observed that beta-lactam antibiotics also have targets in proliferating eukaryotic cells (1), one of which most likely is the replicative DNA polymerase alpha. Here we show that HIV-reverse transcriptase and human DNA polymerase alpha share amino acid sequence homologies to five bacterial penicillin-binding proteins.