Cephalosporins: bacterial resistance measured by penicillin-binding proteins
Garrido, J.; López, F.
Revista Medica de Chile 117(9): 1037-1043
1989
ISSN/ISBN: 0034-9887 PMID: 2519470 Document Number: 336161
Antibacterial potency of cephalosporins depends on inhibition (acylation) of one or more penicillin-binding proteins (PBP). Recently, reduced affinity of PBP for cephalosporins and other B-lactam agents has been found in some cases. Mechanism for these changes in affinity are analyzed in this review.
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