Selectivity of latrotoxin channel in lipid bilayers
Krasil'nikov, O.V.; Sabirov, R.Z.; Ternovskiĭ, V.I.; Merzliak, P.G.; Tashmukhamedov, B.A.
Biofizika 35(5): 801-804
1990
ISSN/ISBN: 0006-3029 PMID: 1707314 Document Number: 348262
It is established that high initial K-TEA and Ca2(+)-K+ selectivity of channel form by latrotoxin in lipid bilayers (LT-channel) may be reduced by lowering the pH value and by increasing electrolytes concentration of solution. It is suggested that LT-channel is water-filled pore cation selectivity which is defined by the electrostatic potential on the mouth of the channel, which is induced by the ionogenic group of toxin.