Effect of 4-cholesten-3-one on lecithin-cholesterol acyltransferase activity and the lipid concentration in the serum of normocholesterolaemic and hypercholesterolaemic rats
Tallová, J.; Dobiásová, M.; Stárka, L.
Physiologia Bohemoslovaca 39(2): 119-123
1990
ISSN/ISBN: 0369-9463 PMID: 2144351 Document Number: 348261
Male Wistar strain rats and PHHC (Prague hereditary hypercholesterolemic) rats received an intraperitoneal injection of 4-cholesten-3-one for five days. Lecithin-cholesterol acyltransferase activity and total cholesterol, triglyceride and phospholipid levels are determined in their serum. A significant drop in the total cholesterol level was found in normocholesterolemic Wistar rats after the administration of cholestenone. The serum triglyceride content remained unaltered and the phospholipid concentration showed downward trend. Lecithin-cholesterol acyltransferase activity was also significantly reduced. In PHHC rats, no significant changes occurred in total cholesterol, triglyceride and phospholipid levels, or in lecithin-cholesterol acyltransferase activity, after the administration of 4-cholesten-3-one. A comparison of serum 4-cholesten-3-one concentrations in the two groups of experimental animals shows that the turnover time for this substance in hypercholesterolemic rats is only half as long as in normocholesterolemic rats.