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Cation-anion selectivity and conductivity of the channels formed by black widow spider whole venom in lipid bilayer

Krasil'nikov, O.V.; Ternovskiĭ, V.I.; Tashmukhamedov, B.A.

Biofizika 28(3): 440-444

1983

ISSN/ISBN: 0006-3029
PMID: 6307397
Document Number: 204499
It is established that BWSV (black widow spider venom) is capable of forming ion channels in lipid bilayer (BPhM). This effect is minimal upon pH value close to 5.0 and is increased either upon oxidation or alkalization of the medium. The amplitudes of the channels are monotonously decreased upon the reduction of pH with simultaneous narrowing of their dispersion. The degree of the change of BPhM conductivity by concentration of BWSV is close to 2 at different pH. Apparently the absorption of the active component of venom on bilayer surface is accompanied by doubling of the degree of its aggregation. Almost ideal cation selectivity of BWSV channels (pH 7.5) is significantly decreased upon the increase in ionic strength. Ionic channel is thought to be a zone of interaction of lipid domains. Possible structure of such a channel is discussed.

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