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Structure of tryptic fragments of a neurotoxin from black widow spider venom

Volkova, T.M.; Galkina, T.G.; Kudelin, A.B.; Grishin, E.V.

Bioorganicheskaia Khimiia 17(4): 437-441

1991

ISSN/ISBN: 0132-3423
PMID: 1888339
Document Number: 386470
The N-terminal amino acid sequence of a neurotoxin from the venom of Latrodectus mactans tredecimguttatus (alpha-latrotoxin) was determined. Latrotoxin was subjected to the tryptic cleavage and total or partial amino acid sequences of 25 peptides were established. In total the tryptic fragments contained 252 amino acid residues. Essential structural information on cloning of the latrotoxin structural gene was obtained.

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