Top Abstract Purchase Related
Home
>
Node
>
Subnode

Use of synthetic analogs of enkephalins as antiatherogenic means

Zoloev, G.K.; Slepushkin, V.D.; Argintaev, E.S.; Prum, I.A.; Sokolovich, G.E.

Biulleten' Eksperimental'noi Biologii i Meditsiny 108(10): 468-470

1989

ISSN/ISBN: 0365-9615
PMID: 2597763
Document Number: 340228
The experiments have been performed on 70 male rats weighing 200-250 gr., 53 patients with obliterating atherosclerosis of lower extremities have been examined. Leu-enkephalin analogues (dalargin and DEFN) administration in a dose of 0.1 mg/kg has been determined to decrease cholesterol levels in the blood in acute and chronic experimental hypercholesterolemia. The use of pharmacological preparation -- enkephalin analogue of dalargin in complex treatment of the obliterating atherosclerosis of lower extremities leads to cholesterol concentration decrease, parathormone concentration decrease in the blood of patients and hyperlactatemia decrease in venous blood of the damaged extremity. Leu-enkephalin analogues, action mechanisms and the possibility of their use for atherosclerosis treatment is discussed.

Document emailed within 1 workday
Secure & encrypted payments

Nakamura, S.; Yoshimatsu, S.; Murakami, K.; Kubota, Y. 1992: Spectroscopic studies of the interaction of synthetic RNAs with quinacrine and its analogs Nucleic Acids Symposium Series 27: 75-76
Petrukhina, G.N.; Makarov, V.A. 1995: Possible aspects of the use of prostacyclin, prostaglandin E1 and their synthetic analogs in medical practice Eksperimental'naia i Klinicheskaia Farmakologiia 58(3): 70-79
Versteeg, D.H.; Gispen, W.H.; Schotmann, P.; Witter, A.; de Wied, D. 1972: Hypophysectomy and rat brain metabolism: effects of synthetic ACTH analogs Advances in Biochemical Psychopharmacology 6: 219-239
Korkhov, V.V.; Lesik, E.A.; Petrosian, M.A. 2005: Gestagenic and contraceptive activity of new synthetic progesterone analogs in experimental animals Eksperimental'naia i Klinicheskaia Farmakologiia 68(1): 39-41
Novikov, V.E.; Iasnetsov, V.V. 1993: The effect of synthetic enkephalin analogs on the development of traumatic brain edema Biulleten' Eksperimental'noi Biologii i Meditsiny 116(8): 125-127
Kazanowska, B.; Steuden, W.; Bogusławska-Jaworska, J.; Konopińska, D. 1987: The influence of synthetic tuftsin and its analogs on the function of granulocytes of children with acute lymphoblastic leukemia Archivum Immunologiae et Therapiae Experimentalis 35(2): 169-173
Skurat, A.V.; Perfil'eva, E.A.; Baranova, L.A.; Khropov, I.V.; Bulargina, T.V. 1982: Activation of adenyl cyclase from bovine brain caudate nucleus by synthetic analogs of guanyl nucleotides Biokhimiia 47(10): 1716-1723
Fedoreeva, L.I.; Gorbach, V.I. 1993: Interaction of the outer membrane pore-forming protein of Yersinia pseudotuberculosis with lipid a and its synthetic analogs Bioorganicheskaia Khimiia 19(10): 933-940
Beltrutti, D.; Debernardi, F.; Pelosi, G. 1997: Analgesic effects of natural growth hormone release inhibitors and their synthetic analogs. Intraspinal administration Minerva Medica 88(1-2): 39-47
Tokovenko, I.P.; Skripal', I.G.; Malinovskaya, L.P.; Bairamova, N.E.; Mochalova, L.V.; Tuzikov, A.B.; Bovin, N.V. 1994: The inhibition of Mycoplasma pneumoniae adhesion in a fetuin test system by synthetic analogs and polymeric forms of neuraminic acid Mikrobiolohichnyi Zhurnal 56(1): 3-9
Sakamoto, S.; Mitamura, T.; Iwasawa, M.; Kitsunai, H.; Shindou, K.; Yagishita, Y.; Zhou, Y.F.; Sassa, S. 1998: Conservative management for perimenopausal women with uterine leiomyomas using Chinese herbal medicines and synthetic analogs of gonadotropin-releasing hormone In Vivo 12(3): 333-337
Gaĭko, O.A.; Kaĭdashev, I.P. 1999: The therapeutic activity of synthetic peptides, analogs of the renal natural peptide complex, in the late periods of a toxic lesion by ethylene glycol Eksperimental'naia i Klinicheskaia Farmakologiia 62(5): 47-51
Beliakova, I.G.; Viktorovskiĭ, I.V.; V'iunov, K.A.; Komarov, E.V. 1989: Oleandomycin and its natural and synthetic analogs. I. Dissociative ionization of oleandomycin and its derivatives Antibiotiki i Khimioterapiia 34(3): 194-199
Suzuki, K.; Nishioka, J.; Hashimoto, S. 1980: Assay method of plasma plasminogen by means of a synthetic fluorogenic peptide substrate (3104-V) Rinsho Byori. Japanese Journal of Clinical Pathology 28(8): 804-807
Beliakova, I.G.; Viktorovskiĭ, I.V.; V'iunov, K.A.; Vorontsov, A.M.; Kanev, A.S. 1989: Oleandomycin and its natural and synthetic analogs. II. Structure and properties of oleandomycin B, a new compound of the oleandomycin group Antibiotiki i Khimioterapiia 34(3): 199-202
Lazarová, Z.; Edelsteinová, S.; Lojda, Z. 1991: The antiatherogenic dose response effect of verapamil in an experimental atherosclerosis model in the rabbit Cor et Vasa 33(6): 480-491
Biriukov, A.I.; Tarusova, N.B.; Amontov, S.G.; Osipova, T.I.; Goriachenkova, E.V. 1985: Organophosphate analogs of biologically active compounds. XIV. Halophosphonate analogs of ATP as acetyl CoA carboxylase inhibitors Bioorganicheskaia Khimiia 11(5): 598-604
Pashevin, D.O.; Dosenko, B.I.; Byts', I.V.; Moĭbenko, O.O. 2009: Antiatherogenic characteristics of korvitin: effect on proteasome activity of the aorta, heart, and blood cells Fiziolohichnyi Zhurnal 55(4): 50-57
Massaro, M.; Carluccio, M.A.; De Caterina, R. 1999: Direct vascular antiatherogenic effects of oleic acid: a clue to the cardioprotective effects of the Mediterranean diet Cardiologia 44(6): 507-513
Hijikata, A.; Okamoto, S.; Kikumoto, R.; Tamao, Y. 1979: Kinetic studies on the selectivity of a synthetic thrombin-inhibitor using synthetic peptide substrates Thrombosis and Haemostasis 42(3): 1039-1045