The therapeutic activity of synthetic peptides, analogs of the renal natural peptide complex, in the late periods of a toxic lesion by ethylene glycol
Gaĭko, O.A.; Kaĭdashev, I.P.
Eksperimental'naia i Klinicheskaia Farmakologiia 62(5): 47-51
1999
ISSN/ISBN: 0869-2092 PMID: 10572753 Document Number: 505758
The purpose of the work was study of the therapeutic activity of synthetic peptides, analogs of the natural renal peptide complexes, in late-term sequelae of a toxic affection caused by oral administration of ethylene glycol. Quite moderate disorders of renal function were encountered in the late-term periods after affection of the hepatic parenchyma. Under such conditions all the peptides under study produced a therapeutic effect, but of a different degree. It is thus obvious that study of these synthetic peptides, analogs of the natural renal complex, as potential drugs for the prevention of late-term toxic disorders of renal function is promising.