Penetration and action of edoxudine in vitro and in vivo
Kaul, R.; Hempel, B.; De Clercq, E.
Arzneimittel-Forschung 39(3): 366-368
1989
ISSN/ISBN: 0004-4172 PMID: 2757660 Document Number: 328278
The penetration of 5-ethyl-2'-deoxyuridine (edoxudine, Aedurid) from gel base with and without the addition of urea and other adjuvant has been studied in an in vitro model using guinea pig skin. The formulation of 3% edoxudine gel with 5% urea showed the best results. In vivo experiments on hairless mice infected intracutaneously with herpes simplex virus type 1 also showed this formulation's good efficacy as compared to other formulations.
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