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The resistance of in vivo selected tumor cells of malignant phenotype to the cytolytic action of activated peritoneal macrophages in vitro

Vol'pe, E.A.

Biulleten' Eksperimental'noi Biologii i Meditsiny 111(2): 177-179

1991

ISSN/ISBN: 0365-9615
PMID: 1854964
Document Number: 373669
Using radioisotope cytolytic 3H-thymidine release assay the sensitivity of low-malignant spontaneously in vitro transformed hamster embryo cells (STHE strain) and its in vivo selected malignant variants (STHE-LM-4, STHE-LM-8, STHE-75/18) as well as Rous sarcoma virus (RSV) (Schmidt-Ruppin strain) tumorigenic transformants (HET-SR-1, TU-SR) were tested to cytolysis by peritoneal Syrian hamster macrophages (MP) activated in vitro with levan, LPS, MDP and PMA. It has been shown that the only parental cells STHE strain (non-selected in vivo) were sensitive to cytolysis by activated MP. All in vivo selected malignant variants of STHE cell sublines as well as tumorigenic RSV-SR-transformants were resistant to cytolysis by activated MP. Thioglycollate-elicited but not activated MP did not destroy any tumour target cells.

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Totpal, K.; Lapushin, R.; Ananthaswamy, H.N.; Aggarwal, B.B. 1991: In vitro selection of NIH-3T3 cells for resistance to lymphotoxin induces resistance to activated macrophages and enhances tumorigenicity in vivo Lymphokine and Cytokine Research 10(5): 359-367
Youdim, S. 1976: Resistance to tumor growth mediated by Listeria monocytogenes. Destruction of experimental malignant melanoma by LM-activated peritoneal and lymphoid cells Journal of Immunology 116(3): 579-584
Fidler, I.J.; Gersten, D.M.; Budmen, M.B. 1976: Characterization in vivo and in vitro of tumor cells selected for resistance to syngeneic lymphocyte-mediated cytotoxicity Cancer Research 36(9 Pt.1): 3160-3165
Vasil'ev, V.I.; Krotkova, M.V.; Popova, E.V.; Shatrova, A.N. 1990: The cytolytic function of mononuclear phagocytes. II. Factors that determine the binding and lysis of tumor cells by activated macrophages Tsitologiia 32(3): 275-281
Chace, J.H.; Fleming, A.L.; Gordon, J.A.; Perandones, C.E.; Cowdery, J.S. 1995: Regulation of differentiation of peritoneal B-1a (CD5+) B cells. Activated peritoneal macrophages release prostaglandin E2, which inhibits IgM secretion by peritoneal B-1a cells Journal of Immunology 154(11): 5630-5636
Chen, M.F.; Suzuki, H.; Yano, S. 1992: Induction of murine lymphokine-activated killer-like cells by Corynebacterium parvum (C. parvum) in vitro: lysis of tumor cells and macrophages by C. parvum-induced killer cells Anticancer Research 12(2): 451-456
Takada, S.; Koide, J.; Engleman, E.G. 1989: Differences in surface phenotype between cytolytic and non-cytolytic CD4+ T cells. MHC class II-specific cytotoxic T lymphocytes lack Leu 8 antigen and express CD2 in high density Journal of Immunology 142(9): 3038-3044
Xiang, J.; Moyana, T. 1998: Cytotoxic CD4+ T cells associated with the expression of major histocompatibility complex class II antigen of mouse myeloma cells secreting interferon-gamma are cytolytic in vitro and tumoricidal in vivo Cancer Gene Therapy 5(5): 313-320
De Baetselier, P.; Kapon, A.; Katsav, S.; Feldman, M.; Segal, S. 1982: Selection of an immunogenic 3LL tumor subline following serial growth in vivo in the local presence of peritoneal macrophages Advances in Experimental Medicine and Biology 155: 281-288
Hess, A.D.; Tutschka, P.J. 1980: Effect of cyclosporin a on human lymphocyte responses in vitro. I. CsA allows for the expression of alloantigen-activated suppressor cells while preferentially inhibiting the induction of cytolytic effector lymphocytes in MLR Journal of Immunology 124(6): 2601-2608
Weinberg, J.B. 1981: In vivo modulation of macrophage tumoricidal activity: enhanced tumor cell killing by peritoneal macrophages from mice given injections of sodium periodate Journal of the National Cancer Institute 66(3): 529-533
Toge, T.; Nakanishi, K.; Yamada, Y.; Yanagawa, E.; Hattori, T. 1981: Scanning electron microscopic studies on the surface structure of activated macrophages and on their interaction with tumor cells Gan 72(2): 305-309
Weil-Hillman, G.; Voss, S.D.; Fisch, P.; Schell, K.; Hank, J.A.; Sosman, J.A.; Sugamura, K.; Sondel, P.M. 1990: Natural killer cells activated by interleukin 2 treatment in vivo respond to interleukin 2 primarily through the p75 receptor and maintain the p55 (TAC) negative phenotype Cancer Research 50(9): 2683-2691
Hatton, D.H.; Mitchell, D.L.; Strickland, P.T.; Johnson, R.T. 1995: Enhanced photoproduct repair: its role in the DNA damage-resistance phenotype of human malignant melanoma cells Cancer Research 55(1): 181-189
Li, L.M.; Nicolson, G.L.; Fidler, I.J. 1991: Direct in vitro lysis of metastatic tumor cells by cytokine-activated murine vascular endothelial cells Cancer Research 51(1): 245-254
Segerson, E.C.; Gunsett, F.C. 1994: In vitro and in vivo effects of lymphokine-activated killer cells upon preattachment ovine conceptuses Journal of Immunology 152(6): 2938-2951
Ax, W.; Dyonysius, J.; Hungerer, K.D. 1979: In vivo and in vitro interaction of Trypanosoma cruzi with mouse macrophages and heart muscle cells--film presentation Advances in Experimental Medicine and Biology 114: 673-676
Sun, D.M.; Hu, X.Z.; Shi, W.; Zhang, Y.H. 1986: Influences of inflammatory macrophages on the proliferation of mouse tumor cells in vitro Zhonghua Zhong Liu Za Zhi 8(4): 247-249
Erb, P.; Grogg, D.; Troxler, M.; Kennedy, M.; Fluri, M. 1990: CD4+ T cell-mediated killing of MHC class II-positive antigen-presenting cells. I. Characterization of target cell recognition by in vivo or in vitro activated CD4+ killer T cells Journal of Immunology 144(3): 790-795
Sudo, H.; Hashimoto, Y. 1971: Enhancement of cytotoxic activity of immune peritoneal lymphocytic cells against antigenic tumor cells after in vitro culture Gan 62(4): 275-281