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The antiaggregant action of 2-morpholino-5- (thienyl-2) -6-H-1,3,4-thiadiazine in in vitro and ex vivo experiments

Logvinova, I.S.; Makarov, V.A.; Chupakhin, O.N.; Sidorova, L.P.; Perova, N.M.; Rusinov, V.L.

Eksperimental'naia i Klinicheskaia Farmakologiia 76(2): 13-16

2013

ISSN/ISBN: 0869-2092
PMID: 23631277
Document Number: 665142
The influence of 2-morpholino-5-(thienyl-2)-6-H-1,3,4-thiadiazine (H-29) on the platelet aggregation has been studied in experiments on donor plasma in vitro. It is established that H-29 causes a decrease in the platelet interaction induced by ADP and arachidonic acid. The influence of H-29 on platelet aggregation was also studied in ex vivo experiments with intravenous and oral administration, and some parameters of plasmatic hemostasis were evaluated.

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