The effect of finoptin on the metabolism and pharmacological action of cyclophosphane in vivo and in vitro
Donenko, F.V.; Chikvashvili, B.S.; Borovkova, N.B.; Devichenskiĭ, V.M.; Kabieva, A.O.; Korneva, E.N.; Telegin, L.I.; Shcherbakov, V.M.; Letiagin, V.P.; Moroz, L.V.
Biulleten' Eksperimental'noi Biologii i Meditsiny 111(3): 300-302
1991
ISSN/ISBN: 0365-9615 PMID: 2054511 Document Number: 367956
Phynoptin (Ph) and cyclophosphamide (CP) gave rise to a type I spectral changes with liver microsomal fraction. KS were 15 microM and 2150 microM, respectively. Ph increases the concentration of NBP product(s) of CP and acrolein in the blood plasma of animals. Ph increases a toxicity of CP. LD50 was 388.0 +/- 13.9 mg/kg for CP and LD50 was 342.8 +/- 16.9 mg/kg for CP in combination with Ph. Ph changes a therapeutic action of CP in mice with hemocytoblastosis La. Pharmacokinetic interactions have been demonstrated between calcium antagonists Ph and CP.