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Effect of carbenoxolone (CBO) on metabolism of nucleic acids, polyamines and proteins of gastric mucosa "in vivo" and "in vitro"

Casti, A.; Morini, G.; Reali, N.; Fior, T.D.; Rabbi, A.

L'Ateneo Parmense. Acta Bio-Medica Organo Della Societa di Medicina e Scienze Naturali di Parma 47(1): 47-58

1976

ISSN/ISBN: 1123-7325
PMID: 1016271
Document Number: 107621
Carbenoxolone was administrated, by intubation per os, to guinea-pigs, then the animals were killed 2 and 4 hours later. In perfusion experiments, carbenoxolone was injected for 5,10 and 20 min respectively. The results show a decreased uptake of formiate-H3 into RNA and DNA in vivo. During perfusion of stomach, CBO causes a precocious enhancement of specific radioactivity of nucleic acids, then a decrease was observed. The pattern of polyamines in perfused stomach shows an increased uptake of putrescine-C14 into spermidine. Finally, the specific radioactivity of proteins was enhanced in vivo and in vitro by CBO. The results demonstrate that the drug alterates the proliferative cell cycle and induces the synthesis of proteins.

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