The effect of gastronomical concentrations of ethanol on therapeutic effect of cimetidine and sucralfate in rats with chronic gastric ulcers
Małecki, I.; Borkowska, B.
Polish Journal of Pharmacology and Pharmacy 41(3): 259-262
1989
ISSN/ISBN: 0301-0244 PMID: 2616385 Document Number: 326606
Chronic peptic ulcers were produced in the glandular part of the stomach by electrocoagulation of gastric mucosa. Drugs: cimetidine (200 mg/kg) and sucralfate (1000 mg/kg) were given intragastrically once daily for 10 or 20 days, together with ethanol, which was given in a daily dose of 1.8 g/kg, as a 5, 15 or 45% solution. The diluted, 5% ethanol did not impair the healing process either in untreated, or cimetidine- or sucralfate-treated rats. Higher concentrations, 15 and 45%, inhibited healing of the ulcers, particularly the drug-assisted healing process. The 45% ethanol solution after 20 days of administration together with cimetidine or sucralfate completely abolished the therapeutic effect of those drugs in rats with chronic peptic ulcers.