Effect of thymoquinone on ethanol and high fat diet induced chronic pancreatitis--a dose response study in rats
Suguna, P.; Geetha, A.; Aruna, R.; Siva, G.V.
Indian Journal of Experimental Biology 51(4): 292-302
2013
ISSN/ISBN: 0019-5189 PMID: 24195349 Document Number: 664051
A significant increase in serum lipase, amylase, capase-1 and myeloperoxidase activities, oxidative stress index (OSI), IL-1beta and IL-18 was observed in rats receiving ethanol (EtOH) and high fat diet (HFD). Thymoquinone (TQ) supplementation along with EtOH and HFD significantly decreased the levels of serum lipase, amylase, capase-1, myeloperoxidase, OSI and maintained the antioxidant status when compared to untreated EtOH and HFD fed rats. Among the 4 doses, 100 mg of TQ/kg body weight was found to provide optimum protective effect on pancreas against EtOH and HFD induced abnormal changes. Histological observations added more evidence for the anti-inflammatory effect of TQ.