Effect of sucralfate on gastric bicarbonate secretion in patients with duodenal ulcer
Singh, K.; Nain, C.K.; Singh, V.; Ganguly, N.K.
Indian Journal of Gastroenterology Official Journal of the Indian Society of Gastroenterology 14(2): 48-50
1995
ISSN/ISBN: 0254-8860 PMID: 7797276 Document Number: 454098
Sucralfate is known to protect gastroduodenal mucosa and thereby facilitate healing of peptic ulcer. The mechanism of action of this drug is still not fully known. We studied the effect of sucralfate treatment on gastric bicarbonate secretion in 16 patients with duodenal ulcer. Sucralfate administration (3 g daily for 4 weeks) stimulated bicarbonate secretion from 3.1 +/- 1.2 mmol/h to 4.6 +/- 2.0 mmol/h (p < 0.05). Gastric juice volume as well as non-parietal volume secretion also increased significantly after sucralfate therapy (p < 0.05). Sucralfate causes stimulation of non-parietal volume-dependent gastric bicarbonate secretion.