The effect of cimetidine on stress ulcers
Sufian, S.; Sugimachi, K.; Leahy, J.A.; Matsumoto, T.
International Surgery 63(3): 143-146
1978
ISSN/ISBN: 0020-8868 PMID: 632033 Document Number: 126324
We used 135 male Wistar rats. Stress ulcers were formed with standard methods of restraints and cold. The severity of the ulcer was graded from 0--3 and determined for each group. Ulcers occurred in the glandular portion of the stomach. Pre- and post-treatment with cimetidine was compared with controls and pre-treatment with saline or antacid. Cimetidine was significantly more effective in preventing stress-induced ulcers in rats when instilled in the stomach before the stress than either antacid or saline.