Effect of tiopronin on prostaglandin synthesis in rabbit kidney medulla slices
Fujita, T.; Fujimoto, Y.; Wada, K.; Kaneko, M.; Sakuma, S.; Iso, T.
Journal of Pharmacy and Pharmacology 40(9): 650-651
1988
ISSN/ISBN: 0022-3573 PMID: 2907036 Document Number: 321363
The effect of 2-mercaptopropionylglycine (tiopronin), which is widely used for the treatment of various hepatic disorders, on the generation of medullary prostaglandins (PG) E2 and F2.alpha. has been examined. Tiopronin had a potent inhibitory effect on PG E2 formation. Simultaneously, PG F2.alpha. production was increased. In the presence of tiopronin the net increased amount of PG F2.alpha. was much smaller than the net decreased amount of PG E2 (6-20%). These results suggest that tiopronin has the potential to modulate PG E2 and F2.alpha. synthesis by affecting endoperoxide E2 isomerase or endoperoxide reductase and that this effect may represent some pharmacological action of the drug.