Top Abstract Purchase Related
Home
>
Node
>
Subnode

Effect of methyl mercury on prostaglandin synthesis in rabbit kidney medulla slices

Fujimoto, Y.; Yabuno, T.; Kato, M.; Nishioka, K.; Fujita, T.

Research Communications in Chemical Pathology and Pharmacology 54(1): 115-119

1986

ISSN/ISBN: 0034-5164
PMID: 3467401
Document Number: 269760
Effects of methylmercuric chloride (MMC) in the absence and presence of ascorbic acid on the synthesis of prostaglandins E2 and F2 alpha, and the lipid peroxidation of rabbit kidney medulla slices were studied. MMC showed dose-dependent inhibition of prostaglandins E2 and F2 alpha formation. The lipid peroxidation was not stimulated by MMC alone. Ascorbic acid plus MMC were able to stimulate the lipid peroxidation markedly, but the lipid peroxidation induced by ascorbic acid plus MMC had no influence on prostaglandin E2 production decreased by MMC alone. These results suggest that MMC inhibits prostaglandin formation by affecting the activity of prostaglandin cyclooxygenase, but that lipid peroxidation is not directly responsible for this inhibitory effect of MMC.

Document emailed within 1 workday
Secure & encrypted payments

Fujita, T.; Fujimoto, Y.; Wada, K.; Kaneko, M.; Sakuma, S.; Iso, T. 1988: Effect of tiopronin on prostaglandin synthesis in rabbit kidney medulla slices Journal of Pharmacy and Pharmacology 40(9): 650-651
Macfarlane, D.E. 1981: The effects of methyl mercury on platelets: induction of aggregation and release via activation of the prostaglandin synthesis pathway Molecular Pharmacology 19(3): 470-476
Mobacken, H.; Ahonen, J.; Zederfeldt, B. 1974: The effect of cationic triphenylmethane dye (crystal violet) on rabbit granulation tissue. Oxygen consumption and RNA and protein synthesis in tissue slices Acta Dermato-Venereologica 54(5): 343-347
Danon, A.; Zenser, T.V.; Thomasson, D.L.; Davis, B.B. 1986: Effect of verapamil on prostaglandin E2 synthesis by hydronephrotic rabbit cortical interstitial cells in primary culture Journal of Pharmacology and Experimental Therapeutics 238(1): 125-130
Fejes-Tóth, G.; Filep, J.; Zahajszky, T.; Fejes-Tóth, A.N. 1986: Effects of vasopressin and prostaglandin synthesis inhibition on cyclic AMP accumulation in the dog renal inner medulla Acta Physiologica Hungarica 67(1): 131-140
Wang, Y.F.; Jin, Y.C.; Wu, Y.E.; Gu, L.J.; Xie, X.H. 1989: The cervix-ripening effect of 15-methyl-prostaglandin F2 alpha methyl ester before vacuum aspiration for termination of early pregnancy in primigravidae Chinese Medical Journal 102(3): 200-202
Shimkovich, M.V.; Pshennikova, M.G. 1986: Effect of preliminary administration of prostaglandin E2 and the prostaglandin synthesis inhibitor indomethacin on disturbances of myocardial contraction during stress Biulleten' Eksperimental'noi Biologii i Meditsiny 101(5): 536-537
Goodman, S.B.; Chin, R.C.; Chiou, S.S.; Lee, J.S. 1991: Suppression of prostaglandin E2 synthesis in the membrane surrounding particulate polymethylmethacrylate in the rabbit tibia Clinical Orthopaedics and Related Research 271: 300-304
Pekkanen, T.J.; Salminen, K. 1972: The effect of ethionine feeding on the retention of a single per os dose of methyl mercury on rat Acta Veterinaria Scandinavica 13(3): 319-322
Liu, P.; Li, J.; Wu, X.; Na, D. 2001: Comparing the two neurobehavioral toxicological methods on the toxic effect of methyl mercury Wei Sheng Yan Jiu 30(6): 321
Gecse, A.; Ottlecz, A.; Faragó, M.; Forster, T.; Telegdy, G. 1980: Effects of ACTH on the synthesis and metabolism of prostaglandin in rat kidney Acta Physiologica Academiae Scientiarum Hungaricae 55(2): 107-112
Aiken, J.W. 1974: Effects of prostaglandin synthesis inhibitors on angiotensin tachyphylaxis in the isolated coeliac and mesenteric arteries of the rabbit Polish Journal of Pharmacology and Pharmacy 26(1): 217-227
Pekkanen, T.J.; Sandholm, M. 1971: The effect of experimental methyl mercury poisoning on the number of sulfhydryl (SH) groups in the brain, liver and muscle of rat Acta Veterinaria Scandinavica 12(4): 551-559
Hauger-Klevene, J.H. 1975: The effect of growth hormone on renin production and release by rat kidney slices Acta Physiologica Latino Americana 25(1): 80-82
Proverbio, F.; Yaris, G.I.; Proverbio, T.; Marín, R. 1986: Effect of norepinephrine on NaCl extrusion in guinea-pig kidney cortex slices Acta Cientifica Venezolana 37(5): 519-525
Jaiswal, N.; Lambrecht, G.; Mutschler, E.; Malik, K.U. 1988: Contribution of M2 alpha and M2 beta muscarinic receptors to the action of cholinergic stimuli on prostaglandin synthesis and mechanical function in the isolated rabbit heart Journal of Pharmacology and Experimental Therapeutics 247(1): 104-113
Mohandas, J.; Duggin, G.G.; Horvath, J.S.; Tiller, D.J. 1981: Regional differences in peroxidatic activation of paracetamol (acetaminophen) mediated by cytochrome P450 and prostaglandin endoperoxide synthetase in rabbit kidney Research Communications in Chemical Pathology and Pharmacology 34(1): 69-80
Wack, A.; Woermann, C.; Braun, W. 1982: A study of the probenecid effect on amino acid accumulation in kidney cortex slices Archives Internationales de Pharmacodynamie et de Therapie 256(2): 292-300
Higashihara, E.; Pillai, V.; Kokko, J.P. 1985: Cortical and papillary micropuncture study of water transport in segments of the rat kidney during inhibition of prostaglandin synthesis Nihon Jinzo Gakkai Shi 27(9): 1317-1328
Urban, I. 1976: The effect of ACTH on oxygen uptake by skeletal muscle, brain, liver, kidney and myocardium slices of the rat Acta Physiologica Polonica 27(5): 471-476