The effect of ACTH on oxygen uptake by skeletal muscle, brain, liver, kidney and myocardium slices of the rat
Urban, I.
Acta Physiologica Polonica 27(5): 471-476
1976
ISSN/ISBN: 0044-6033 PMID: 188305 Document Number: 97395
Using Wartburg's method the effect of ACTH on oxygen uptake by slices of various tissues of the rat was investigated in relation to the duration of ACTH action in the organism. A reduction in oxygen uptake by tissue slices was found 1 hour after ACTH injection with a rise after 16 hours. It seems that in the first phase ACTH exerts an inhibitory effect on tissue respiration indirectly through the adrenal cortex, while in the second phase it may exert a stimulatory influence either directly or by some other mechanisms.