Tumor necrosis factor-alpha up-regulates expression of secretory component, the epithelial receptor for polymeric Ig
Kvale, D.; Løvhaug, D.; Sollid, L.M.; Brandtzaeg, P.
Journal of Immunology 140(9): 3086-3089
1988
ISSN/ISBN: 0022-1767 PMID: 3361127 Document Number: 319431
Secretory component (SC) is the receptor that facilitates transcytosis of polymeric IgA and polymeric IgM through secretory epithelial cells and into exocrine fluids. The present study showed that rTNF-alpha enhanced the cellular pool, membrane expression, and secretion of functionally SC in a human colonic carcinoma cell line (HT-29m2) which is known to express and process SC like normal glandular cells. TNF-alpha also up-regulated membrane expression of the constitutive HLA class I molecules, whereas the cells remained HLA class II-negative.
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